Correlation Between Homocysteine and Lipid Parameters in Patients with End-Stage Renal Disease
Semir Hrvo1, Irma Dizdarevic1, Amila Muratspahic1, Refet Gojak1, Berina Hasanefendic2, Amir Sandzic3, Senad Murtic4
1 Clinic for Infectious Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
2 Clinical Biochemistry and Laboratory Medicine, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
3 Institute for Transfusion Medicine of the Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina
4 Inel-Med Limited Liability Company, Mostar, Bosnia and Herzegovina
Corresponding Author: Semir Hrvo MD. Clinic for Infectious Diseases, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina; E-mail: hrvosemir@gmail.com; Phone: +387 61 546-794; ORCID ID: https://orcid.org/0000-0002-1731-6859.
Cite this article: Hrvo S, Dizdarevic I, Muratspahic A, Gojak R, Hasanefendic B, Sandzic A, et al. Correlation Between Homocysteine and Lipid Parameters in Patients with End-Stage Renal Disease. Sar Med J. 2025;
2(1):15-19. 
10.70119/0030-25
Pages: 15 – 19 / Published online: 20 June 2025
Original submission: 19 February 2025; Revised submission: 16 April 2025; Accepted: 25 April 2025
Abstract
Introduction. Chronic kidney insuffi ciency presents a progressive decline in renal function. Long-term hemodialysis treatments lead to biochemical parameter imbalances like an altered level of homocysteine (Hcy). Hcy can contribute to oxidative stress and endothelial damage, which promotes the accumulation of low-density lipoprotein (LDL) cholesterol and the deve-lopment of atherosclerosis. It can also aff ect lipoprotein metabolism and trigger infl ammatory processes that alter the lipid profi le, especially increasing triglycerides and lowering high-density lipoprotein (HDL) cholesterol.
Methods. This cross-sectional, clinical and descriptive-analytical study included 83 patients, 40 patients on hemodialysis, and 43 subjects in healthy control group.
Results. The hemodialysis group had signifi cantly higher Hcy values compared to the control group of seemingly healthy subjects (p<0.05). The control group had signifi cantly higher values of total cholesterol, LDL and very low-density lipoprotein (VLDL) compared to the hemodialysis patients (p<0.05). There was non signifi cant correlation between Hcy and lipid parameters in the hemodialysis group, neither in the control group.
Conclusion. Patients undergoing hemodialysis had signifi cantly higher total homocysteine le-vels compared to the control group. However, total homocysteine did not demonstrate an asso-ciation with lipid status parameters in either the hemodialysis patients or the healthy subjects.
Keywords: homocysteine, hemodialysis, cholesterol, triglycerides, metabolism.
